About November 19, 1823

Palmyra, New York
Joseph Smith's brother Alvin died at age 25. He had been ill with "bilious colic" and was given a dose of calomel, which may have killed him.
Sources: 
History of the Church, Joseph Smith, 1:2, 16
History of Joseph Smith by His Mother Lucy Mack Smith, ch. 20
Joseph Smith History A-1:1, 7 Joseph Smith History, 
Sustaining the Law: Joseph Smith's Legal Encounters Gordon A. Madsen, Jeffrey N. Walker, and John W. Welch, 
Winter Quarters

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